HORDB

ID: hor004259
Uniprot ID: B3TZ51
Protein name: Tachykinin-related peptide
Gene name: NA
Organism: Homarus americanus (American lobster)
Family: Tachykinin family
Source: animal
Expression: supraoesophageal ganglion (brain), commissural ganglia (CoGs) and midgut
Disease: NA
Comments: NA
Taxonomy: Homarus (genus), Nephropidae (family), Nephropoidea (superfamily), Astacidea (infraorder), Pleocyemata (suborder), Decapoda (order), Eucarida (superorder), Eumalacostraca (subclass), Malacostraca (class), Multicrustacea (superclass), Crustacea (subphylum), Pancrustacea, Mandibulata, Arthropoda (phylum), Panarthropoda, Ecdysozoa, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: NA
GO BP: NA
GO CC: NA

Sequence: TPSGFLGMR
Length: 9
Propeptide: MMEVRRGCCSCPLLSTVCVRMVRACTWAVLLGVVVVMGVVSAAGEGQDTPQDRERRAPSGFLGMRGKKDASTALDDNTAASEYSSLPDPYPLYGLRDNNLPMLFAVPWKTKKAPSGFLGMRGKKSDEEVFSDATADNDLEILLKRAPSGFLGMRGKKAPSGFLGMRGKKAPSGFLGMRGKKYYDDDSDMDAYIQALTAVVDGQQQQKRAPSGFLGMRGKKAYYSENPDEEISMTGVDKRTPSGFLGMRG
Signal peptide: NA
Modification: NA
Glycosylation: NA
Mutagenesis: NA

Function: Elicit identical increases in both heart contraction frequency and amplitude;
Mechanism: NA
Cross BBB: NA
Target: NA
Target Unid: NA
IC50: NA
EC50: NA
ED50: NA
kd: NA
Half life: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

hor004259_AF2.pdb

hor004259_ESM.pdb

Mass:	110800	Formula:	C42H68N12O12S
Absent amino acids:	ACDEHIKNQVWY	Common amino acids:	G
pI:	10.55	Basic residues:	1
Polar residues:	4	Hydrophobic residues:	2
Hydrophobicity:	1.11	Boman Index:	-876
Half-Life:	7.2 hour	Half-Life Yeast:	>20 hour
Half-Life E.Coli:	>10 hour	Aliphatic Index	43.33
Instability Index:	2191.11	Extinction Coefficient cystines:	0
Absorbance 280nm:	0

PubMed ID: 18706463
Title: Identification and Cardiotropic Actions of Brain/Gut-Derived Tachykinin-Related Peptides (TRPs) From the American Lobster Homarus Americanus